Pharmacokinetics of Sulfatroxazole in Cows and Sheep

Authors

  • L.D.B. Kinabo Department of Veterinary Physiology, Biochemistry, Pharmacology and Toxicology, Sokoine University of Agriculture, Morogoro, Tanzania
  • R.D. Mosha Department of Veterinary Physiology, Biochemistry, Pharmacology and Toxicology, Sokoine University of Agriculture, Morogoro, Tanzania
  • A.J. Ngomuo Department of Veterinary Physiology, Biochemistry, Pharmacology and Toxicology, Sokoine University of Agriculture, Morogoro, Tanzania
  • P. Nielsen Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Copenhagen, Denmark

Keywords:

Cow, Sheep, Pharmacology,, Physiology, Veterinary

Abstract

The disposition of sulfatroxazole (STZ) was studied in 6 cows and 6 sheep following intravenous injection of a single dose (30mg/kg body weight).  The distribution of STZ was fast in the cows and in the Sheep. The elimination of STZ was significantly faster from sheep (309 ± 82 minutes) than from cows (404 ± 39 minutes). The total body clearance was higher in sheep (0.70 ± 0.13 ml/min/kg body weight) than in cow (0.49 ± 0.11 ml/min/kg body weight). The apparent volume of distribution made up about 30% of the body weight in both species. The presence of N4-acetyl-STZ in plasma showed that metabolism is involved in elimination of STZ from both cows and sheep

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Published

30-06-1988

How to Cite

Kinabo, L., Mosha, R. ., Ngomuo, A. and Nielsen, P. (1988) “Pharmacokinetics of Sulfatroxazole in Cows and Sheep”, Tanzania Veterinary Journal, 8(1), pp. 1–5. Available at: https://tvj2.sua.ac.tz/vet2/index.php/TVJ/article/view/319 (Accessed: 28 April 2026).

Issue

Vol. 8 No. 1 (1988)

Section

RESEARCH ARTICLES

License

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