The Effect Of Feeding on: II: Plasma Triglycerides Flow and Uptake By The Liver In Normal Adult Sheep

Abstract

Plasma triglycerides (TG) were measured in portal hepatic veins and arterial blood before, during and after feeding grass hay.  In order to determine the liver uptake or output portal blood flows were measured by a continuous creatinine infusion method. Arterial plasma TG concentration in fasted and fed adult sheep was 0.204±0.02 and 0.282±0.02 mmole/L respectively while the venous plasma TG was 0.151+0.01 and 0.184+0.02 mmole/L respectively. No apparent change in plasma TG concentration was noted when sheep were fed.  Post feeding TG release from the splanchnic tissues was 0.006±0.001 mmole/min.kg ^0.73 as opposed to 0.004±0.002 mmole/min. kg ^0.73 during the fasted state. During feeding and for a few hours (2-4) post-feeding the hepatic TG uptake was 0.009±0.004 mmole/min. kg ^0.73 in contrast to 0.006±0.002 mmole/min.  kg ^0.73  during fasted state